Lake of the Isles Park is this insane chain of three lakes with little islands in the middle and bustling city all around. It is a supremely pleasant place to walk/jog/bike, or simply sit and gawk at the city's skyline and the natives' adorable dogs.
If you need to bring some snacks or hooch to the park (I don't even know if that's allowed), hit up Kowalski's on the way. It's like a cheaper, local-centric Whole Foods with a great wine selection.
LynLake Brewery: I liked the Rubbish Oat Amber Ale and Sideburns Milk Stout because that's how I roll, but my friend's pint of Dirty Heffer with Pineapple was pretty good, too.
Muddy Waters, open daily from 8am to 2am keeps the kind of rock and roll hours I wish I could. I had Cuban hash with chorizo, black beans, yucca, chiles, and eggs, with a great cup of coffee, but I would totally go back and try some of their many whiskeys when I don't have a presentation to give.
Quang is affordable, super fresh Vietnamese and seems to be kind of an institution in the 'hood. Get ready to have your heart broken on Tuesdays, though, because they are closed that day.
Spyhouse is a Minneapolis coffee chain, but I don't feel bad going there because Minneapolis is so super cool, anyway. Their baked goods are nice and I would describe their coffee is very "coffee flavored".
Art that is not exactly in Uptown, but it's walkable and you should go:Minneapolis is a great city to visit if you love art. Please visit all of these places when you go.
Walker Art Center: contemporary visual arts and design exhibitions; dance, theater, and music performances; and film screenings. Free admission first Saturday of every month and all Thursdays from 5-9pm. They're the ones with the big spoon with a cherry on it outside.
Minneapolis Institute of Art: This place is free. Seriously. They have some nice Chagall right now, too.
Minneapolis College of Art and Design: Also free and student-run; it is very exciting to see what great art students are inventing right now!
The American Swedish Institute is a beautiful castle-like structure with an amazing amount of history and art, and the even make good (albeit Swedish) food in the cafe. There's another one for Danish people somewhere, but who cares.