I used Pittsburgh as my home base last week for a couple of university appearances, and I will preface this post with the truth: you could spend a lot more time in Pitt doing a lot more super cool things. But here's a little something to get you started while you're buying your opera tickets and looking up all your favorite galleries.
Coca Cafe has to-die-for egg sandwiches with kimchi, excellent coffee, and a chill, funky vibe just a few blocks off the Allegheny River. Afterwards, talk a short hilly stroll to enjoy the Art Deco architecture of Arsenal Middle School and the grandiose Zion Evangelical Lutheran Church, which kind of transports you back to Victorian Europe. Pints on Penn makes for a break across the street from 19th Century composer Stephen Foster's home, too.
Authentic family-style Italian-American food is pretty easy to come by in Pittsburgh, but I loved Sarafino's for its raucous close-knit atmosphere, perfectly dressed pasta (the red clam sauce was delish), and a soaked almond creme cake which puts all other cakes to shame. They don't serve alcohol, so make like the locals and come prepared with your own bottle or two (or in one case, a martini shaker and various bottles of brightly-colored liquors). Big Daddy's Donuts is good, too, but be forewarned, they're not actually open 24/7 as some websites might say. They are super fresh.
Some other cools stuff to see:
Andy Warhol Museum
Heinz History Center, with a display of Mr. Rogers' Neighborhood
Nationality Rooms at University of Pittsburgh, honoring the various origins of Pittsburgh's melting pot